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Research shows that if you regularly use nicotine it can disrupt the cerebral dopamine pathway, amplify stress sensitivity and distort coping mechanisms that buffer against depressive symptoms.

Research shows an association with increased frequency of nicotine use and depression, - aka the more you use it, the more depressed you can get.

E-cigarette use among high schoolers increased 77.8% in 2018 over 2017, with similar trends observed internationally.

Evidence suggests nicotine delivered via e-cigarettes may have the same negative physiological effects that are observed with combustible cigarettes use.

In the U.S., smoking results in 5.4 million years of potential life lost each year.

E-cigarettes can produce a stress response in neural stem cells.

The long-term activation of the stress response system and the overexposure to cortisol and other stress hormones that follows can disrupt almost all your body's processes. This puts you at increased risk of many health problems, including: anxiety, depression, digestive problems, headaches, muscle tension and pain, heart disease, heart attack, high blood pressure, sleep problems, weight gain, memory and concentration impairment. 

While JUUL claimed they were taking steps to reduce youth vaping, they were hiring more than 80 lobbyists to undermine efforts to ban flavored pods — which have been proven to be enticing to first-time, young vapers.

Vape companies — including JUUL — have been known to advertise at music festivals and events with young attendees, and have even sponsored scholarships.