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In 2015 , the opioid epidemic cost the US more than 500 billion dollars.

Source: The Council of Economic Advisers. The Underestimated Cost of the Opioid Crisis. Washington, DC: Executive Office of the President; 2017.
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Since 1999, over 9,000 children and teens have died from opioid overdoses.

Source: Centers for Disease Control and Prevention. CDC WONDER: Multiple Cause of Death 1999-2017.
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Opioids can cause constipation.

Source: Lee, A.A. & Hasler, W.L. Curr Treat Options Gastro (2016) 14: 478.
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Heroin-related overdose deaths increased 5x from 2010 to 2017.

Source: Scholl L, Seth P, Kariisa M, Wilson N, Baldwin G. Drug and Opioid-Involved Overdose Deaths — United States, 2013–2017. MMWR Morb Mortal Wkly Rep 2019;67:1419–1427. DOI: http://dx.doi.org/10.15585/mmwr.mm675152e1.
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According to the CDC, healthcare providers wrote 259M prescriptions for opioid pain relievers in 2012, which is enough for every adult in America to fill one prescription.

Source: Paulozzi LJ, Mack KA, Hockenberry JM. Vital signs: variation among states in prescribing of opioid pain relievers and benzodiazepines—United States, 2012. MMWR Morb Mortal Wkly Rep 2014;63:563–8.
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Adolescent athletes in some high-injury sports are at a 50% higher risk of misusing prescription painkillers than their peers who don't participate in these sports.

Source: Veliz PT, Boyd C, McCabe SE. Playing through pain: sports participation and nonmedical use of opioid medications among adolescents. Am J Public Health. 2013;103(5):e28–e30. doi:10.2105/AJPH.2013.301242
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In 2016, 1 in 5 deaths among young adults were opioid related.

Source: Gomes T, Tadrous M, Mamdani MM, Paterson J, Juurlink DN. The burden of opioid-related mortality in the united states. JAMA Network Open. 2018;1(2):e180217.
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Individuals who are prescribed opioids prior to graduating high school are 33% more likely to misuse prescription opioids after graduating.

Source: Prescription Opioids in Adolescence and Future Opioid Misuse Richard Miech, Lloyd Johnston, Patrick M. O’Malley, Katherine M. Keyes, Kennon Heard Pediatrics Nov 2015, 136 (5) e1169-e1177; DOI: 10.1542/peds.2015-1364
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More than 17,000 people died from prescription opioid overdoses in 2017.

Source: Scholl L, Seth P, Kariisa M, Wilson N, Baldwin G. Drug and Opioid-Involved Overdose Deaths — United States, 2013–2017. MMWR Morb Mortal Wkly Rep 2019;67:1419–1427. DOI: http://dx.doi.org/10.15585/mmwr.mm675152e1
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103,000 adolescents had an opioid use disorder in 2017.

Source: Substance Abuse and Mental Health Services Administration. (2018). Key substance use and mental health indicators in the United States: Results from the 2017 National Survey on Drug Use and Health (HHS Publication No. SMA 18-5068, NSDUH Series H-53). Rockville, MD: Center for Behavioral Health Statistics and Quality, Substance Abuse and Mental Health Services Administration.
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In 2011, more than 420,000 emergency department visits were related to the misuse or abuse of narcotic pain relievers.

Source: Substance Abuse and Mental Health Services Administration, Drug Abuse Warning Network, 2011: National Estimates of Drug-Related Emergency Department Visits. Rockville, MD: Substance Abuse and Mental Health Services Administration; 2013.
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In 2012, every 25 minutes, a baby was born suffering from opioid withdrawal.

Source: Patrick SW, Davis MM, Lehmann CU, Cooper WO. Increasing incidence and geographic distribution of neonatal abstinence syndrome: United States 2009 to 2012 [published correction appears in J Perinatol. 2015 Aug;35(8):667. Lehman, C U [corrected to Lehmann, C U]]. J Perinatol. 2015;35(8):650–655. doi:10.1038/jp.2015.36
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