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More than two-thirds of people admitted into substance abuse treatment programs first used a non-heroin opioid by age 25.

Source: Substance Abuse and Mental Health Services Administration, Center for Behavioral Health Statistics and Quality. Treatment Episode Data Set (TEDS): 2003-2013. National Admissions to Substance Abuse Treatment Services. Rockville, MD: Substance Abuse and Mental Health Services Administration, 2015.
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In 2017, two out of three drug overdose deaths involved some type of opioid.

Source: Scholl L, Seth P, Kariisa M, Wilson N, Baldwin G. Drug and Opioid-Involved Overdose Deaths — United States, 2013–2017. MMWR Morb Mortal Wkly Rep 2019;67:1419–1427. DOI: http://dx.doi.org/10.15585/mmwr.mm675152e1.
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In 2010, every 3 minutes, a woman went to the ER for prescription painkiller misuse.

Source: Centers for Disease Control and Prevention. Vital Signs: Overdoses of Prescription Opioid Pain Relievers and Other Drugs Among Women — United States, 1999–2010. MMWR 2013;62:537-542.
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Every day, 130 Americans die after overdosing on opioids.

Source: Hedegaard H, Miniño AM, Warner M. Drug overdose deaths in the United States, 1999–2017. NCHS Data Brief, no 329. Hyattsville, MD: National Center for Health Statistics. 2018.
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Non-addictive painkillers, like ibuprofen and acetaminophen, can be just as effective as prescription opioids at reducing certain types of pain.

Source: Chang AK, Bijur PE, Esses D, Barnaby DP, Baer J. Effect of a Single Dose of Oral Opioid and Nonopioid Analgesics on Acute Extremity Pain in the Emergency DepartmentA Randomized Clinical Trial. JAMA.2017;318(17):1661–1667. doi:10.1001/jama.2017.16190
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In 2017, 10.3 million young adults used a prescription opioid.

Source: Center for Behavioral Health Statistics and Quality. (2018). 2017 National Survey on Drug Use and Health: Detailed Tables. Substance Abuse and Mental Health Services Administration, Rockville, MD.
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In 2017, 47,600 people died of opioid overdoses in America.

Source: Hedegaard H, Miniño AM, Warner M. Drug overdose deaths in the United States, 1999–2017. NCHS Data Brief, no 329. Hyattsville, MD: National Center for Health Statistics. 2018.
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In 2016, enough painkillers were prescribed to medicate every American adult 30 mg of hydrocodone every day for almost a month.

Source: Guy GP Jr., Zhang K, Bohm MK, et al. Vital Signs: Changes in Opioid Prescribing in the United States, 2006–2015. MMWR Morb Mortal Wkly Rep 2017;66:697–704. DOI: http://dx.doi.org/10.15585/mmwr.mm6626a4
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The prescribing rates for controlled substances among adolescents and young adults nearly doubled from 1994 to 2007.

Source: Fortuna RJ, Robbins BW, Caiola E, Joynt M, Halterman JS. Prescribing of controlled medications to adolescents and young adults in the United States. Pediatrics. 2010;126(6):1108-1116.
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JUUL (or pod-based e-cigs) can deliver more nicotine than a cigarette.

Source: Stella Juhyun Lee, PhD1; Vaughan W. Rees, PhD2; Noam Yossefy, MPH2; et al. (2020, June 1). Youth and Young Adult Use of Pod-Based Electronic Cigarettes From 2015 to 2019. Retrieved from https://jamanetwork.com/journals/jamapediatrics/article-abstract/2766303.
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JUUL (or pod-based e-cigs) have a higher potential for nicotine dependence than other types of e-cigarettes.

Source: Stella Juhyun Lee, PhD1; Vaughan W. Rees, PhD2; Noam Yossefy, MPH2; et al. (2020, June 1). Youth and Young Adult Use of Pod-Based Electronic Cigarettes From 2015 to 2019. Retrieved from https://jamanetwork.com/journals/jamapediatrics/article-abstract/2766303.
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