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The opioid mortality rate increased as the U.S. life expectancy rate decreased.

Source: Xu JQ, Murphy SL, Kochanek KD, Bastian B,Arias E. Deaths: Final data for 2016. National Vital Statistics Reports; vol 67 no 5. Hyattsville, MD: National Center for Health Statistics. 2018.
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Smokers are more likely to be opioid abusers than non-smokers.

Source: Zale EL, Dorfman ML, Hooten WM, Warner DO, Zvolensky MJ, Ditre JW. Tobacco Smoking, Nicotine Dependence, and Patterns of Prescription Opioid Misuse: Results From a Nationally Representative Sample. Nicotine Tob Res. 2014;17(9):1096-103.
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In 2017, 70% of overdose deaths in D.C. involved fentanyl or its analogues.

Source: Leak C. Opioid-related Fatal Overdoses: January 1, 2014 to December 31, 2017. Government of the District of Columbia Office of the Chief Medical Examiner. 2018.
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There were 1.68 million potential years of life lost to opioids in the United States in 2016.

Source: Gomes T, Tadrous M, Mamdani MM, Paterson JM, Juurlink DN. The Burden of Opioid-Related Mortality in the United States. JAMA Netw Open. 2018;1(2):e180217. doi:10.1001/jamanetworkopen.2018.0217
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In 2010, every 3 minutes, a woman went to the ER for prescription painkiller misuse.

Source: Centers for Disease Control and Prevention. Vital Signs: Overdoses of Prescription Opioid Pain Relievers and Other Drugs Among Women — United States, 1999–2010. MMWR 2013;62:537-542.
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Adolescent athletes in some high-injury sports are at a 50% higher risk of misusing prescription painkillers than their peers who don't participate in these sports.

Source: Veliz PT, Boyd C, McCabe SE. Playing through pain: sports participation and nonmedical use of opioid medications among adolescents. Am J Public Health. 2013;103(5):e28–e30. doi:10.2105/AJPH.2013.301242
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In 2015 , the opioid epidemic cost the US more than 500 billion dollars.

Source: The Council of Economic Advisers. The Underestimated Cost of the Opioid Crisis. Washington, DC: Executive Office of the President; 2017.
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Every day in 2017, an estimated 1,300 young adults misused an opioid prescription for the first time.

Source: Substance Abuse and Mental Health Services Administration. (2018). Key substance use and mental health indicators in the United States: Results from the 2017 National Survey on Drug Use and Health (HHS Publication No. SMA 18-5068, NSDUH Series H-53). Rockville, MD: Center for Behavioral Health Statistics and Quality, Substance Abuse and Mental Health Services Administration.
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In 2017, two out of three drug overdose deaths involved some type of opioid.

Source: Scholl L, Seth P, Kariisa M, Wilson N, Baldwin G. Drug and Opioid-Involved Overdose Deaths — United States, 2013–2017. MMWR Morb Mortal Wkly Rep 2019;67:1419–1427. DOI: http://dx.doi.org/10.15585/mmwr.mm675152e1.
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103,000 adolescents had an opioid use disorder in 2017.

Source: Substance Abuse and Mental Health Services Administration. (2018). Key substance use and mental health indicators in the United States: Results from the 2017 National Survey on Drug Use and Health (HHS Publication No. SMA 18-5068, NSDUH Series H-53). Rockville, MD: Center for Behavioral Health Statistics and Quality, Substance Abuse and Mental Health Services Administration.
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Opioids can cause constipation.

Source: Lee, A.A. & Hasler, W.L. Curr Treat Options Gastro (2016) 14: 478.
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As the death rate of major killers like cancer and heart disease decline, opioid death rates continue to rise.

Source: National Center for Health Statistics. Health, United States, 2014: With Special Feature on Adults Aged 55-64. Hyattsville, MD. 2015. https://www.cdc.gov/nchs/data/hus/hus14.pdf. Accessed June 2018.
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